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Products Details
Product Description
– Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC50 of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration[1].
Web ID
– HY-155392
Shipping
– Room temperature
Molecular Formula
– C38H45N9O5S2
References
– [1]Laura Sinatra, et al. Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J Med Chem. 2023 Nov 9;66(21):14787-14814.
Molecular Weight
– 771.95
SMILES
– O=C(NC1=NC=C(S1)CC2=CC=CC(OCC3=CN(N=N3)CCCCC(N(CC4=CC=C(C=C4)C(NO)=O)CCCC)=O)=C2)CSC5=NC(C)=CC(C)=N5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;Sirtuin
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
