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MtTMPK-IN-9
SKU
HY-146703-Get quote
Category Reference compound
Tags Anti-infection;Apoptosis, Bacterial;Thymidylate Synthase, Infection
Products Details
Product Description
– MtTMPK-IN-9 (compound 28) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 48 μM. MtTMPK-IN-9 has sub-micromolar activity against mycobacteria (MICs = 6.25~9.4 μM) without significant cytotoxicity. MtTMPK-IN-9 can be used for researching tuberculosis[1].
Web ID
– HY-146703
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H26N6O7
References
– [1]Jian Y, et al. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur J Med Chem. 2020;206:112659.
Molecular Weight
– 522.51
SMILES
– CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC=C(C=C3)CNC(C4=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C4)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;Thymidylate Synthase
Pathway
– Anti-infection;Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.