Download Files:
Products Details
Product Description
– mTORC1-IN-1 (T1) is a rapamycin homologue (rapalog) and selective mTORC1 inhibitor. mTORC1-IN-1 regulates cell growth and metabolism and is implicated in a variety of diseases including cancer. mTORC1-IN-1 targets mTORC1 by binding to the FKBP12-FRB complex (docking score = −11.6 kcal/mol)[1].
Web ID
– HY-157167
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C50H77NO12
References
– [1]Lopez J J D, et al. The role of glycerol-water mixtures in the stability of FKBP12-rapalog-FRB complexes [J]. Journal of Molecular Graphics and Modelling, 2023: 108556.
Molecular Weight
– 884.15
SMILES
– CC([C@@H]1CC[C@@H](C[C@H]([C@H](C2)OC([C@@H]3CCCCN3C(C([C@@]4(O)[C@H](C)CC[C@@H](C[C@H](O)/C=C/C=C/C=C/[C@H](C[C@@H](C)C([C@H](O)[C@@H](/C(C)=C/[C@@H](C)C2=O)O)=O)C)O4)=O)=O)=O)C)CC1)(C)O
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mTOR
Isoform
– mTORC1
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
