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Products Details
Product Description
– mTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].
Web ID
– HY-155211
Shipping
– Room temperature
Molecular Formula
– C24H22N6O2S
References
– [1]Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9.
CAS Number
– 1144075-44-4
Molecular Weight
– 458.54
SMILES
– O=C(NC1=CC=C(C2=NC3=C(C(N4C[C@@H]5O[C@@H](CC5)C4)=N2)SC=C3)C=C1)NC6=CC=CN=C6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– mTOR;PI3K
Isoform
– mTOR;PI3Kα
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
