Download Files:
Products Details
Product Description
– MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder.
Web ID
– HY-139620
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C52H55ClN10O8S2
References
– [1]Wei J, et al. Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. J Am Chem Soc. 2021 Sep 22;143(37):15073-15083.
CAS Number
– 2762181-19-9
Molecular Weight
– 1047.64
SMILES
– O=S1(C2=CC=CC=C2O[C@H](C)CN1CC3=CC([C@@H](C4=CC(OCCNC(CNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O)=C(N(C)N=N9)C9=C4)CC(OCC)=O)=CC=C3C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PROTACs
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
