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Products Details
Product Description
– MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker[1].
Web ID
– HY-149306
Shipping
– Room temperature
Molecular Formula
– C57H66FN9O6S
References
– [1]Kabir M, et al. Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. J Am Chem Soc. 2023 Jul 12;145(27):14932-14944.
Molecular Weight
– 1024.25
SMILES
– CC1=CSC(C2=CC=C(C3=C2)C4=C(N3CC)C=CC(CNCCOCCOCCOCCN5C=C(N=N5)COC6=C(C=C(C=C6)CCC7=NC8=C(N7CCN9CCOCC9)C=CC(C%10=C(ON=C%10C)C)=C8)F)=C4)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Acetyltransferase;MDM-2/p53
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
