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Products Details
Product Description
– MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells[1].
Web ID
– HY-100360A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H26Cl2N2O
References
– [1]Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Oct 13;59(19):9124-9139.
CAS Number
– 2095432-59-8
Molecular Weight
– 321.29
SMILES
– CNCCN1CCC(OCC2=CC=CC=C2)CC1.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Isoform
– PRMT4;PRMT6
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
