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MS023 (dihydrochloride)
$66 – $825
Products Details
Product Description
– MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].
Web ID
– HY-19615B
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H27Cl2N3O
References
– [1]Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.|[2]Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.
CAS Number
– 1992047-64-9
Molecular Weight
– 360.32
Compound Purity
– 99.78
SMILES
– CC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 150 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Target
– Histone Methyltransferase
Isoform
– PRMT1;PRMT3;PRMT6;PRMT8
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
