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Products Details
Product Description
– MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1].
Web ID
– HY-123099
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H18N2O3
References
– [1]Kim BH, et al. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010 Jan;148(1):132-43.
CAS Number
– 1255516-86-9
Molecular Weight
– 346.38
SMILES
– O=C(C1=CC=C2C=CC=CC2=C1O)NCCC3=CNC4=C3C=C(O)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JAK
Isoform
– JAK3
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
