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MRS2500 (tetraammonium)
$980 – $2,850
Products Details
Product Description
– MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (Ki=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Antithrombotic activity[1][2][3].
Web ID
– HY-108658
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C13H30IN9O8P2
References
– [1]Hechler B, et al. MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther. 2006;316(2):556-563.|[2]Cattaneo M, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004;68(10):1995-2002.|[3]Wong PC, et al. The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. J Thromb Thrombolysis. 2016;41(3):514-521.
CAS Number
– 630103-23-0
Molecular Weight
– 629.28
Compound Purity
– 99.85
SMILES
– O=P(O[C@@H]1[C@]2(COP(O[NH4])(O[NH4])=O)C[C@]2([H])[C@@H](N3C=NC4=C(NC)N=C(I)N=C34)C1)(O[NH4])O[NH4]
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– P2Y Receptor
Isoform
– P2Y1 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
