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Product Description
– MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pKB=8.05)[1][2][3].
Web ID
– HY-108657
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C13H18ClN5O8P2
References
– [1]Nandanan E, et al. Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem. 2000;43(5):829-842.|[2]Boyer JL, et al, Ravi RG, Jacobson KA, Harden TK. 2-Chloro N(6)-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y(1) receptor antagonist. Br J Pharmacol. 2002;135(8):2004-2010.|[3]Wei W, et al. Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release. Bioengineered. 2022 Feb;13(2):2346-2359.
CAS Number
– 367909-40-8
Molecular Weight
– 469.71
SMILES
– O=[P](O)(O)OC[C@]1([C@H]2O[P](O)(O)=O)[C@]([C@](N3C4=NC(Cl)=NC(NC)=C4N=C3)([H])C2)([H])C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– P2Y Receptor
Isoform
– P2Y1 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
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