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MRK-740
$130 – $1,150
Products Details
Product Description
– MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 µM)[1].
Web ID
– HY-114209
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H32N6O3
References
– [1]Abdellah Allali-Hassani, et al. Discovery of a Chemical Probe for PRDM9. Nat Commun. 2019 Dec 17;10(1):5759.
CAS Number
– 2387510-80-5
Molecular Weight
– 464.56
Compound Purity
– 99.21
SMILES
– CC1=NC=CC(N(CC2)CCC32CN(C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)CCN3C)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 40 mg/mL (ultrasonic;warming)
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
