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Mps1-IN-1 (dihydrochloride)
$582 – $931
Products Details
Product Description
– Mps1-IN-1 dihydrochloride is a potent and ATP-competitive Mps1 kinase inhibitor with an IC50 of 367 nM. Mps1-IN-1 dihydrochloride inhibit Mps1 mitotic kinase activity and abrogates spindle assembly checkpoint (SAC) function. Mps1-IN-1 dihydrochloride decreases the viability of both cancer and ‘normal’ cells[1].
Web ID
– HY-110347
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H35Cl2N5O4S
References
– [1]Nicholas Kwiatkowski, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68.
CAS Number
– 1883548-93-3
Molecular Weight
– 608.58
SMILES
– OC1CCN(C2=CC=C(NC3=CC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5C(NC=C5)=N3)C(OC)=C2)CC1.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Mps1
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
