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MPP (dihydrochloride)
$420
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Products Details
Product Description
– MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].
Web ID
– HY-103454
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H33Cl2N3O3
Citations
– Biomolecules. 2023 Jul 10, 13(7), 1097.|Drug Resist Updat. 2023 Oct 26:71:101014.|Ecotoxicol Environ Saf. 2023 May 23;259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Jul 5;e2100070.|Phytomedicine. 2023 Nov 14:123:155218.|Phytomedicine. 27 February 2022, 154022.|Food Chem Toxicol. 2023 Apr 18;113792.|Metab Brain Dis. 2022 Jul 2.
References
– [1]KaraboÄŸa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672.|[2]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.|[3]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73(8):1034-44.
CAS Number
– 911295-24-4
Molecular Weight
– 542.50
Compound Purity
– 99.06
SMILES
– OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology
Solubility
– DMSO : 30 mg/mL (ultrasonic;warming)
Target
– Apoptosis;Estrogen Receptor/ERR
Isoform
– ERα;ERβ
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
