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Products Details
Product Description
– MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
Web ID
– HY-147691
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H24N6O2
References
– [1]Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.
CAS Number
– 2476764-11-9
Molecular Weight
– 428.49
SMILES
– NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Glutathione Peroxidase;Potassium Channel
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
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