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Products Details
Product Description
– MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
Web ID
– HY-147691
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H24N6O2
References
– [1]Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.
CAS Number
– 2476764-11-9
Molecular Weight
– 428.49
SMILES
– NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Glutathione Peroxidase;Potassium Channel
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
