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Motesanib (Diphosphate)
$66 – $370
Products Details
Product Description
– Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.
Web ID
– HY-10229
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H29N5O9P2
Citations
– Oncotarget. 2016 Sep 27;7(39):63839-63855.|Cell Physiol Biochem. 2018;48(1):227-236. |Harvard Medical School LINCS LIBRARY|J Cell Biochem. 2020 Mar;121(3):2343-2353.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
References
– [1]Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21.|[2]Kruser TJ, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res, 2010, 16(14), 3639-3647.|[3]Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15(1), 110-118.
CAS Number
– 857876-30-3
Molecular Weight
– 569.44
Compound Purity
– 99.64
SMILES
– O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC(NCC4(C)C)=C4C=C3.O=P(O)(O)O.O=P(O)(O)O
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– DMSO : ≥ 110 mg/mL|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– c-Kit;VEGFR
Isoform
– VEGFR1/Flt-1;VEGFR2/KDR/Flk-1;VEGFR3/Flt-4
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
