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Products Details
Product Description
– MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively[1].
Web ID
– HY-147638
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H24ClFN4O3
References
– [1]McArthur JR, et al. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. Br J Pharmacol. 2018 Jun;175(12):2284-2295.
CAS Number
– 1909225-94-0
Molecular Weight
– 458.91
SMILES
– N/C(N)=NCCCOC1=CC=C(C=C1)C(NC2=C(C=CC=C2)OC3=CC=C(C=C3)F)=O.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel
Isoform
– N-type calcium channel;T-type calcium channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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