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Mongersen
$400 – $2,050
Products Details
Product Description
– Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn’s disease-like experimental colitis in mice[1][2].
Web ID
– HY-145721
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C200H241N69O107P20S20
References
– [1]Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn’s disease. N Engl J Med. 2015 Mar 19;372(12):1104-13.|[2]Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24(6):1213-1224.
CAS Number
– 1443994-46-4
Molecular Weight
– 6584.00
Compound Purity
– 95.25
SMILES
– [Mongersen]
Clinical Information
– Phase 3
Research Area
– Inflammation/Immunology
Solubility
– H2O : 20 mg/mL (ultrasonic)
Target
– TGF-beta/Smad
Pathway
– Stem Cell/Wnt;TGF-beta/Smad
Product type
– Oligonucleotides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
