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Monastrol
$61 – $770
Products Details
Product Description
– Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
Web ID
– HY-101071A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C14H16N2O3S
References
– [1]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4.|[2]Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280(13):12658-67.|[3]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288.
CAS Number
– 329689-23-8
Molecular Weight
– 292.35
Compound Purity
– 99.70
SMILES
– O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 33 mg/mL
Target
– Apoptosis;Kinesin
Isoform
– Kinesin-5/Eg5/KSP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
