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Monactin
$636
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Products Details
Product Description
– Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].
Web ID
– HY-111525
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C41H66O12
References
– [1]Graven SN, et al. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966;5(5):1735-1742.|[2]Murer H, et al. On the mechanism of sugar and amino acid interaction in intestinal transport. J Biol Chem. 1975;250(18):7392-7396.|[3]Harinantenaina Rakotondraibe L, et al. Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett. 2015;25(23):5646-5649.|[4]Tamai, Y, et al. Nonactin and related compounds found in a screening program for wnt signal inhibitory activity. Heterocycles, 84(2), 1245-1250.|[5]Harold FM, et al. Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cells. J Bacteriol. 1968;95(3):816-823.
CAS Number
– 7182-54-9
Molecular Weight
– 750.96
SMILES
– CC[C@@H](OC([C@@H]([C@H]1O[C@@](C[C@@H](OC([C@H]([C@@](CC2)([H])O[C@@]2([H])C3)C)=O)C)([H])CC1)C)=O)C[C@]4([H])O[C@@]([C@@H](C(O[C@H](C[C@@]5([H])O[C@H]([C@H](C(O[C@@H]3C)=O)C)CC5)C)=O)C)([H])CC4
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial
Pathway
– Anti-infection
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
