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Products Details
Product Description
– MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
Web ID
– HY-141836
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H21F3N4O2
References
– [1]Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.
CAS Number
– 1450666-97-3
Molecular Weight
– 442.43
SMILES
– O=C(N1CCC(O)CC1)C(C=C2)=CC=C2C3=CN=C(N)C(C4=CC=C(C(F)(F)F)C=C4)=N3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
