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MMV390048
$165 – $1,375
Products Details
Product Description
– MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].
Web ID
– HY-106005
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H14F3N3O2S
References
– [1]Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.
CAS Number
– 1314883-11-8
Molecular Weight
– 393.38
Compound Purity
– 99.17
SMILES
– NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3
Clinical Information
– Phase 2
Research Area
– Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Parasite;PI4K
Isoform
– Plasmodium
Pathway
– Anti-infection;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
