Download Files:
Products Details
Product Description
– MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and MMP-9 inhibitor with IC50 values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation[1].
Web ID
– HY-147867
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H16IN7S
References
– [1]Omar AM, et al. Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects. Bioorg Chem. 2020 Aug;101:103992.
CAS Number
– 2415311-84-9
Molecular Weight
– 441.29
SMILES
– C/C(C1=C(C)N=C(N/N=C/C2=CC=C(I)C=C2)S1)=NNC(N)=N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MMP
Isoform
– MMP-2;MMP-9
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
