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MM-206
$231 – $370
Products Details
Product Description
– MM-206, a STAT3 activity inhibitor, potently inhibits the STAT3 SH2 domain-phosphopeptide interaction with IC50 of 1.2 μM. MM-206 demonstrates dose-dependent induction of apoptosis in acute myeloid leukemia (AML) cell lines[1].
Web ID
– HY-121725
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H12F5NO3S2
References
– [1]A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment. Blood.2015 Dec 3.126 (23): 569.
CAS Number
– 1809581-87-0
Molecular Weight
– 497.46
SMILES
– O=S(C1=C(C(F)=C(C(F)=C1F)F)F)(NC2=C3C=CC=CC3=C(C(SC4=CC=CC=C4)=C2)O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– STAT
Pathway
– JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
