Download Files:
MM-102 (TFA)
$60 – $912
Products Details
Product Description
– MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki 200 times more potent than the ARA peptide.
Web ID
– HY-12220A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C37H50F5N7O6
Citations
– Cell Death Dis. 2022 Sep 6;13(9):770.|J Mol Endocrinol. 2021 Jan;66(1):45-57.|Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966. |Acta Pharmacol Sin. 2021 Apr 13.
References
– [1]Karatas H, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135(2):669-682.
CAS Number
– 1883545-52-5
Molecular Weight
– 783.83
Compound Purity
– 99.77
SMILES
– O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3.FC(F)(F)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
