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MM-102
$60 – $912
Products Details
Product Description
– MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction, with IC50= in WDR5 binding assay 2.4 nM, Ki< 1 nM.
Web ID
– HY-12220
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C35H49F2N7O4
Citations
– Acta Pharmacol Sin. 2021 Apr 13.|Cell Death Dis. 2022 Sep 6;13(9):770.|J Mol Endocrinol. 2021 Jan;66(1):45-57.|Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966.
References
– [1]Karatas H, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013, 135(2), 669-682.
CAS Number
– 1417329-24-8
Molecular Weight
– 669.80
Compound Purity
– 99.17
SMILES
– O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
