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ML299
SKU
HY-116273-Get quote
Category Reference compound
Tags Cancer, Metabolic Enzyme/Protease, Phospholipase
Products Details
Product Description
– ML299 is a selective allosteric modulator and a dual inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML299 decreases invasive migration in U87-MG glioblastoma cells[1].
Web ID
– HY-116273
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H26BrFN4O2
References
– [1]O’Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56(6):2695-9.
CAS Number
– 1426916-00-8
Molecular Weight
– 489.38
SMILES
– O=C(C1=CC=C(C=C1)Br)N[C@H](CN2CCC3(N(CNC3=O)C4=CC=CC(F)=C4)CC2)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Phospholipase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.