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ML291
$90 – $850
Products Details
Product Description
– ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].
Web ID
– HY-101991
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H16ClN3O6S
References
– [1]Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128(22):3523.
CAS Number
– 1523437-16-2
Molecular Weight
– 413.83
Compound Purity
– 99.74
SMILES
– O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(Cl)CC3)=O)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 50 mg/mL
Target
– Apoptosis;Eukaryotic Initiation Factor (eIF);PERK
Isoform
– eIF2
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
