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ML198
$95 – $1,500
Products Details
Product Description
– ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-117861
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C17H14N4O
References
– [1]Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase.
CAS Number
– 1380716-06-2
Molecular Weight
– 290.32
Compound Purity
– 98.0
SMILES
– O=C(NC1=CC=C(C=C1)C#C)C2=C3N=C(C=C(N3N=C2)C)C
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 5 mg/mL (ultrasonic;warming;adjust pH to 2 with HCl;heat to 60°C)
Target
– Glucosidase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
