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Products Details
Product Description
– MK2-IN-1 is a highly efficient and selective inhibitor of MAPKAPK2 (MK2) kinase, with an IC50 value of 0.11uM.
Web ID
– HY-12834
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H25ClN4O2
Citations
– Cell Rep. 2021 Nov 2;37(5):109949.|Cell Death Dis. 2021 Oct 23;12(11):994.
References
– [1]Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1068-72.|[2]Huang X, et al. A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70.|[3]Huang X, et al. Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors. ACS Med Chem Lett. 2011 Jun 24;2(8):632-7.
CAS Number
– 1314118-92-7
Molecular Weight
– 472.97
SMILES
– O=C(C1=CC=C(C2=CC=C(Cl)C=C2)O1)N(C3=CC=C(N4CCNCC4)C=C3)CC5=NC=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MAPKAPK2 (MK2)
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
