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MK-8745
SKU
HY-13819-10 mg
Category Reference compound
Tags Apoptosis;Aurora Kinase, Apoptosis;Cell Cycle/DNA Damage;Epigenetics, Cancer
$45 – $185
Products Details
Product Description
– MK-8745 is an aurora A kinase inhibitor with an IC50 of 0.6 nM.
Web ID
– HY-13819
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H19ClFN5OS
References
– [1]Jayasree S Nair et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent.|[2]Aparajita Chowdhury et al. A novel Aurora kinase A inhibitor MK-8745 predicts
TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines.
Leuk Lymphoma, 2012 Mar, 53(3):462-71.
CAS Number
– 885325-71-3
Molecular Weight
– 431.91
Compound Purity
– 99.49
SMILES
– O=C(C1=CC=CC(Cl)=C1F)N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Apoptosis;Aurora Kinase
Isoform
– Aurora A
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.