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Products Details
Product Description
– MK-8262 is an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor with an IC50 of 53 nM and a log D of 5.3. MK-8262, a bistrifluoromethyl analogue, has the potential for coronary heart disease (CHD) correlated high-density lipoprotein (HDL) and low-density lipoprotein (LDL) research[1].
Web ID
– HY-132303
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C35H25F9N2O5
References
– [1]Petr Vachal, et al. Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties. J Med Chem. 2021 Aug 10.
CAS Number
– 1432054-03-9
Molecular Weight
– 724.57
SMILES
– O=C(O)C1=CC=C(C2=CC(C3=CC=C(C(F)(F)F)C=C3[C@@H]4CC[C@]5([H])N4C(O[C@@H]5C6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6)=O)=C(OC)N=C2)C(C)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– CETP
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
