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MK 0893
$378 – $1,710
Products Details
Product Description
– MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.
Web ID
– HY-50663
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C32H27Cl2N3O4
References
– [1]Xiong Y, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.J Med Chem. 2012 Jul 12;
CAS Number
– 870823-12-4
Molecular Weight
– 588.48
Compound Purity
– 99.86
SMILES
– ClC1=CC(C2=NN(C(C3=CC4=C(C=C3)C=C(OC)C=C4)=C2)[C@H](C5=CC=C(C=C5)C(NCCC(O)=O)=O)C)=CC(Cl)=C1
Clinical Information
– Phase 2
Research Area
– Metabolic Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)
Target
– GCGR
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
