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Products Details
Product Description
– MK-0736 (Compounds 1) is highly potent and selective inhibitor of 11β-HSD1. MK-0736 can be used for the research of type 2 diabetes, hypertension and metabolic syndrome[1].
Web ID
– HY-112290
Shipping
– Room temperature
Molecular Formula
– C23H30F3N3O2S
References
– [1]Sukrut Shah, et al. Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. J Am Soc Hypertens. 2011 May-Jun;5(3):166-76. |[2]Bauman DR, et al. Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3650-3.
CAS Number
– 719272-79-4
Molecular Weight
– 469.56
SMILES
– FC(C1=CC=CC=C1C2=NN=C(C3(CC4)CCC4(CCCS(=O)(CC)=O)CC3)N2C)(F)F
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– 11β-HSD
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
