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MK-0354
$180 – $792
Products Details
Product Description
– MK-0354 is a specific GPR109a receptor agonist, acting on hGPR109a/mGPR109a, with EC50 of 1.65 μM and 1.08 μM respectively, and has no effect on GPR109b.
Web ID
– HY-13008
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C7H8N6
References
– [1]Semple G, et al. 3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice. J. Med. Chem., 2008, 51 (16), pp 5101-5108|[2]Lai E1, et al. Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol. 2008 Oct;2(5):375-383.
CAS Number
– 851776-28-8
Molecular Weight
– 176.18
Compound Purity
– 99.59
SMILES
– C12=C(CCC2)C(C3=NN=NN3)=NN1
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– DMSO : ≥ 36 mg/mL
Target
– GPR109A
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
