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Mizacorat
SKU
HY-120012-10 mg
Category Reference compound
Tags Glucocorticoid Receptor, Immunology/Inflammation;Vitamin D Related/Nuclear Receptor, Inflammation/Immunology; Endocrinology
$650 – $950
Products Details
Product Description
– Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1].
Web ID
– HY-120012
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H28F2N4O3
References
– [1]Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61(5):1785-1799.
CAS Number
– 1893415-00-3
Molecular Weight
– 494.53
Compound Purity
– 99.71
SMILES
– CC(F)(F)C(N[C@H]([C@H](OC1=CC2=C(N(C(C=C3)=CN(C)C3=O)N=C2)C=C1)C4=CC=CC=C4)C(C)C)=O
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– Glucocorticoid Receptor
Pathway
– Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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