Download Files:
Mitoquinone (mesylate)
$90 – $280
Products Details
Product Description
– Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage[1].
Web ID
– HY-100116A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C38H47O7PS
Citations
– Acta Pharm Sin B. 21 July 2021.|Acta Pharmacol Sin. 2021 Jul 22.|Aging Cell. 2021 Aug 30;e13468.|Am J Cancer Res. 2021 Mar 1;11(3):691-711.|Antimicrob Agents Chemother. 2023 May 4;e0009823.|Antioxidants (Basel). 2022 Apr 19;11(5):799.|Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303.|Biomaterials. 2022 Dec 30;294:121986.|Biomaterials. 2022, 121986.|Brain. 2021 Nov 29;144(10):3126-3141.|Cancer Lett. 2021 Aug 1;512:1-14.|Cell Death Dis. 2021 Sep 8;12(9):839.|Cell Death Dis. 2022 Jun 6;13(6):531.|Cell Metab. 2020 Dec 17;S1550-4131(20)30656-2.|Cell Metab. 2023 Jan 3;35(1):200-211.e9.|Cell Rep. 2020 Nov 3;33(5):108340.|Chemosphere. 2023 Feb 24;138249.|Commun Biol. 2022 Jul 22;5(1):726.|Curr Biol. 2020 Sep 7;30(17):3378-3396.e7.|Ecotoxicol Environ Saf. 2022 Jan 29;232:113219.|Ecotoxicol Environ Saf. 2022 Jun 15;238:113595.|Ecotoxicol Environ Saf. 2023 Oct 1, 264, 115409.|EMBO J. 2023 Jul 6;e113258.|EMBO Rep. 2021 Apr 6;e51532.|EMBO Rep. 2023 Jun 26;e56635.|Eur J Pharm Sci. 2022 Dec 7;106350.|Exp Cell Res. 2021 Nov 18;112934.|Exp Mol Med. 2023 Mar 3.|Fachbereich Biologie. 2020 Oct.|Free Radic Biol Med. 2021 Feb 17;S0891-5849(21)00093-9.|Int Immunopharmacol. 2021 Jan;90:107149.|Int J Mol Sci. 2023 May 24, 24(11), 9176.|J Agric Food Chem. 2021 Jun 30.|J Dairy Sci. 2023 Sep 18;S0022-0302(23)00686-0.|J Exp Med. 2021 Sep 6;218(9):e20202637.|J Inflamm Res. 3 August 2022.|J Mol Cell Biol. 2022 Dec 23;mjac073.|J Tradit Chinese Medical Sci. 2023 Feb 10.|Lat Am J Pharm. 2023 Feb 16; 42(1).|Mediat Inflamm. 2020 Aug 17;2020:3934769.|Mol Ther. 2021 Jun 7;S1525-0016(21)00313-0.|Nat Commun. 2022 Aug 6;13(1):4583.|Nat Commun. 2023 Jul 24;14(1):4456.|Neurotoxicology. 2023 Jan 27;S0161-813X(23)00018-9.|Oncogene. 2021 Nov 12.|Oxid Med Cell Longev. 01 Jun 2022.|Oxid Med Cell Longev. 14 Aug 2021.|Oxid Med Cell Longev. 2021 Aug 31;2021:5608133.|Oxid Med Cell Longev. 2022 Sep 20;2022:2213503.|Patent. US20230088747A1.|PLoS One. 2021 Jan 12;16(1):e0245155.|Redox Biol. 2020 Sep;36:101604.|Redox Biol. 2021 Aug 18;46:102113.|Redox Biol. 2021 Jul;43:101977.|Redox Biol. 2021, 101936.|Redox Biol. 2022 Feb;49:102216.|Redox Biol. 2022 Jun 15;54:102367.|Research Square Preprint. 2021 Jul.|Research Square Preprint. 2023 Jul 24.|Research Square Preprint. 2023 Sep 1.|Sci Total Environ. 2021 Nov 24;151899.|SSRN. 16 Feb 2022.|SSRN. 2023 May 22.|Toxicol Appl Pharmacol. 2023 Mar 7;116452.|Toxicol In Vitro. 2022 Jul 13;105436.|Toxicol In Vitro. 2022 Oct 19;105487.|Toxicol Res (Camb). 08 September 2022.|Toxicology. 2023 Feb 24;487:153466.|Biomed Pharmacother. 2020 Jun;126:110040.|Biomed Pharmacother. 2023 Apr 12;162:114680.|Chem Eng J. 2020 May.|Front Microbiol. 2023 Oct 31.|J Exp Clin Cancer Res. 2020 Jun 23;39(1):119.|J Neurosci Res. 2019 Dec;97(12):1689-1705. |J Transl Med. 2022 May 14;20(1):222.|Oxid Med Cell Longev. 2019 Dec 3;2019:5820415.|Oxid Med Cell Longev. 2020 Mar 3;2020:2167129. |PLoS Pathog. 2023 May 8;19(5):e1011381.|Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19635-19645. |Toxicol Appl Pharmacol. 2019 May 1;370:78-92.
References
– [1]Mitchell T, et al. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renaltubular cells and rat kidneys. J Pharmacol Exp Ther. 2011 Mar;336(3):682-92.|[2]Huang W, et al. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm. 2015;2015:901780.
CAS Number
– 845959-50-4
Molecular Weight
– 678.81
Compound Purity
– 98.45
SMILES
– [O-]S(=O)(C)=O.O=C(C(CCCCCCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=C4C)C(OC)=C(OC)C4=O
Clinical Information
– Phase 4
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
