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Product Description
– Mipsagargin (G-202) is a novel thapsigargin-based targeted proagent consisting of a prostate-specific membrane antigen (PSMA)-specific peptide coupled to an analog of the potent sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump inhibitor Thapsigargin (HY-13433). Mipsagargin is activated by PSMA-mediated cleavage of an inert masking peptide. Mipsagargin has the potential for refractory, advanced or metastatic solid tumours research[1][2][3].
Web ID
– HY-16215
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C66H100N6O27
References
– [1]John T Isaacs, et al. Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics. Molecules. 2021 Dec 9;26(24):7469.|[2]Samuel R Denmeade, et al. Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy. |[3]D Mahalingam, et al. Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours. Br J Cancer. 2016 Apr 26;114(9):986-94.
CAS Number
– 1245732-48-2
Molecular Weight
– 1409.52
SMILES
– CC1=C([C@@](OC2=O)([H])[C@]3([C@@]2(O)C)O)[C@]([C@](C)(C[C@@H]3OC(CCCCCCCCCCCNC(C[C@H](N)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)OC(C)=O)([H])[C@H](OC(CCCCCCC)=O)[C@H]1OC(/C(C)=CC)=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Drug-Linker Conjugates for ADC
Isoform
– Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– Reference compound
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