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Minodronic acid
$32 – $250
Products Details
Product Description
– Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].
Web ID
– HY-16322
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H12N2O7P2
References
– [1]Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61.|[2]Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.
CAS Number
– 180064-38-4
Molecular Weight
– 322.15
Compound Purity
– 98.0
SMILES
– OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=C2C=CC=CN21
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 5 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic;warming)
Target
– Apoptosis;P2X Receptor
Isoform
– P2X2 Receptor;P2X3 Receptor
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
