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Products Details
Product Description
– Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.
Web ID
– HY-147728
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H19FN2O5
References
– [1]Ding Z,et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.
CAS Number
– 2416338-65-1
Molecular Weight
– 446.43
SMILES
– O=C(C1=CC=CC(/C=C2NC(/C(NC2=O)=C/C3=CC=C(O3)COC)=O)=C1)C4=CC=C(C=C4)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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