Download Files:
Products Details
Product Description
– Compounds 17O (ic50= 14.0 nm, NCI-H460) and 17p (ic50= 2.9 nm, NCI-H460) and furan groups showed effective cytotoxic activity against various human cancer cell lines at the nanomolar level.
Web ID
– HY-147728
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H19FN2O5
References
– [1]Ding Z,et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.
CAS Number
– 2416338-65-1
Molecular Weight
– 446.43
SMILES
– O=C(C1=CC=CC(/C=C2NC(/C(NC2=O)=C/C3=CC=C(O3)COC)=O)=C1)C4=CC=C(C=C4)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
