Products Details

Product Description

– Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization[1].

Web ID

– HY-147727

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C24H19FN2O5

References

– [1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.

CAS Number

– 2416338-64-0

Molecular Weight

– 434.42

SMILES

– COCC1=CC=C(O1)/C=C2NC(/C(NC2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Microtubule/Tubulin

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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