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Products Details
Product Description
– Microtubule inhibitor 6 (compound 17o) is a potent microtubule inhibitor. Microtubule inhibitor 6 shows cytotoxicity with IC50s of 14.0, 6.6, 7.0 nM for NCI-H460, BxPC-3, HT-29 cells, respectively. Microtubule inhibitor 6 efficiently inhibits microtubule polymerization[1].
Web ID
– HY-147727
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H19FN2O5
References
– [1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.
CAS Number
– 2416338-64-0
Molecular Weight
– 434.42
SMILES
– COCC1=CC=C(O1)/C=C2NC(/C(NC2=O)=C/C3=CC(OC4=CC=C(C=C4)F)=CC=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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