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Products Details
Product Description
– Microtubule inhibitor 5 (compound 17f) is a potent microtubule inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC50 value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability[1].
Web ID
– HY-147726
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H15FN2O4
References
– [1]Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435.
CAS Number
– 2416338-55-9
Molecular Weight
– 390.36
SMILES
– O=C1N/C(C(N/C1=CC2=CC(OC3=CC=C(C=C3)F)=CC=C2)=O)=CC4=CC=CO4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
