Products Details

Product Description

– Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity[1].

Web ID

– HY-139981

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C22H26N4O4

References

– [1]Linyu Yang, et al. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):15379-15401.

CAS Number

– 2850370-28-2

Molecular Weight

– 410.47

SMILES

– CN(C1=NC(C)=NC2=CC=CC=C12)C3=CC(OC(C(C)C)C(NO)=O)=C(OC)C=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Microtubule/Tubulin

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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