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Miclxin
$290 – $3,100
Products Details
Product Description
– Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1].
Web ID
– HY-138301
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C26H27N5O2
References
– [1]Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204.
CAS Number
– 2494198-61-5
Molecular Weight
– 441.52
Compound Purity
– 99.48
SMILES
– COC1=CC(CNC2=C3C=CC(OC)=CC3=NC(N4CC(C5=CC=CN=C5)CC4)=N2)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Target
– β-catenin
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
