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Products Details
Product Description
– mHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington’s disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1].
Web ID
– HY-150245
Shipping
– Room temperature
Molecular Formula
– C18H19N7OS
References
– [1]Brom, et al. Preparation of thiazolopyrimidinone derivatives and uses thereof. World Intellectual Property Organization, WO2022194801 A1. 2022-09-22.
CAS Number
– 2839311-21-4
Molecular Weight
– 381.45
SMILES
– O=C1C=C(C2=NN3C=C(C)N=C3C(C)=C2)N=C4SC(N5CCNCC5)=CN14
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Huntingtin
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
