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Product Description
– Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure[1][2].
Web ID
– HY-113071
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C6H12O4
Citations
– Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Biomedicines. 2022, 10(10), 2489.|Drugs R D. 2023 Oct 17.|Acta Pharm Sin B. 2023 Apr 17.|Acta Pharmacol Sin. 2021 Feb 19.|Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Aug 16;159217.|Cell Biosci. 2021 Oct 9;11(1):179.|Life Sci Alliance. 2022 Jan 4;5(3):e202101256.
References
– [1]Moschetti A, et al. Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine. 2021 Oct;37:102439. |[2]Soma MR, et al. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992 Dec;64-65 Spec No:1-15.
CAS Number
– 150-97-0
Molecular Weight
– 148.16
Compound Purity
– 99.0
SMILES
– O=C(O)CC(C)(O)CCO
Clinical Information
– Phase 3
Research Area
– Metabolic Disease; Neurological Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
