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Product Description
– Metoprolol-d5 is the deuterium labeled Metoprolol[1]. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[2][3][4].
Web ID
– HY-17503S3
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C15H20D5NO3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783.|[3]Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1547(2):195-201.|[4]Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018 10(4): 124-129.|[5]Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring18(2):161-5.
CAS Number
– 959786-79-9
Molecular Weight
– 272.39
SMILES
– CC(C)NC([2H])([2H])C(O)([2H])C([2H])([2H])OC1=CC=C(C=C1)CCOC
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;Apoptosis
Pathway
– Apoptosis;GPCR/G Protein;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
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