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Products Details
Product Description
– Metioprim is a competitive inhibitor of bacterial Dihydrofolate reductase (DHFR). Metioprim has inhibitory activity against anaerobic bacteria. Metioprim shows synergistic activity in combination with DDS (HY-B0688) against E. coli. and various mycobacteria[1][2].
Web ID
– HY-122289
Shipping
– Room temperature
Molecular Formula
– C14H18N4O2S
References
– [1]Wüst J, et al. Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria. Antimicrob Agents Chemother. 1983 Mar;23(3):490-2. |[2]Seydel JK, et al. Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI). Chemotherapy. 1983;29(4):249-61. |[3]Nielsen P, et al. Pharmacokinetics and metabolism of metioprim in pigs and goats. Pharmacol Toxicol. 1987 Nov;61(5):330-4.
CAS Number
– 68902-57-8
Molecular Weight
– 306.38
SMILES
– NC1=NC(N)=C(CC2=CC(OC)=C(C(OC)=C2)SC)C=N1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial;Dihydrofolate reductase (DHFR)
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
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