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Methylene Blue
$50 – $95
Products Details
Product Description
– Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation[1][2][3].
Web ID
– HY-14536
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H18ClN3S
References
– [1]Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94(2):65-72. |[2]Hochgräfe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25.|[3]Fenn AM, et, al. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma. 2015 Jan 15;32(2):127-38.
CAS Number
– 61-73-4
Molecular Weight
– 319.85
Compound Purity
– 98.08
SMILES
– CN(C)C1=CC=C2C(SC(C(C=C/3)=N2)=CC3=[N+](C)/C)=C1.[Cl-]
Clinical Information
– Launched
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– Guanylate Cyclase;Microtubule/Tubulin;Monoamine Oxidase;NO Synthase
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Dye Reagents
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
