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Products Details
Product Description
– MET/PDGFRA-IN-2 (compound 8h) is a MET and PDGFRA protein inhibitor. MET/PDGFRA-IN-2 induces cell apoptosis. MET/PDGFRA-IN-2 inhibits proliferation of MET-positive cells (IC50s: 9.7, 6.1, 12.0, 11.5, 8.6, 34.4 μM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, K562 cells respectively)[1].
Web ID
– HY-149511
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H29N7O
References
– [1]Mortazavi M, et al. Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties. Sci Rep. 2023 Sep 6;13(1):14685.
Molecular Weight
– 491.59
SMILES
– CC(C1=CC=C(C=C1)CN2N=NC(COC3=CC=C(C=C3)/C=N/NC4=C5C=CC=CC5=NC=N4)=C2)(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;c-Met/HGFR;PDGFR
Isoform
– PDGFRα
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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